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KMID : 1377020130100050260
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Tissue Engineering and Regenerative Medicine
2013 Volume.10 No. 5 p.260 ~ p.265
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Retinyl retinoate, a retinoid derivative improves acne vulgaris in double-blind, vehicle-controlled clinical study
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Kim Bo-ra
Kim Hyun-Jung
Kim Jin-Eun
Lee Seung-Hun
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Abstract
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Topical retinoids have been an important therapy used in the treatment of acne. However, retinoids often have adverse effects that range from mild to moderate local irritation. Retinyl retinoate is a member of a new generation of well-tolerated synthetic retinoids used as a topical retinoid treatment. To assess retinyl retinoate 0.05% for acne vulgaris therapy, fifteen female patients with mild to moderate facial acne prevalence were included in a double-blind, placebo-controlled, split-face trial for 8 weeks by investigators and measurement of sebum amount. In addition, retinyl retinoate was measured in anti-bacterial efficacy by an agar plate diffusion assay. Retinyl retinoate showed a significant decrease in both inflammatory and non-inflammatory lesions, and in sebum amount at 8 weeks (P < 0.05). The application of retinyl retinoate is effective and no local side effects for acne lesions. Retinyl retinoate had somewhat anti-bacterial activity against Propionibacterium acnes (P. acnes). These results indicate that retinyl retinoate can be used as treatment for mild acne or could potentiate the efficiency of an additive anti-acne agent. Retinyl retinoate is possible to be suggested as a topical anti-acne treatment with excellent tolerance.
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KEYWORD
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topical retinoid, retinyl retinoate, acne vulgaris, sebum
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